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Association between serum antibodies to periodontal bacteria and rheumatoid factor in NHANES III

Identifieur interne : 000A37 ( Main/Exploration ); précédent : 000A36; suivant : 000A38

Association between serum antibodies to periodontal bacteria and rheumatoid factor in NHANES III

Auteurs : Charlene E. Goh [États-Unis] ; Jacob Kopp [États-Unis] ; Panos N. Papapanou [États-Unis] ; Jerry A. Molitor [États-Unis] ; Ryan T. Demmer [États-Unis]

Source :

Arthritis & rheumatology (Hoboken, N.J.) [ 2326-5191 ] ; 2016.

RBID : PMC:5042803

Abstract

Objective

Alterations in the microbiome, including the periodontal microbiome, may be a risk factor for rheumatoid arthritis (RA). Most studies that have analyzed this association are relatively small, focus primarily on a single periodontal pathogen (Porphyromonas gingivalis), and are not population-based. We investigated the association between elevated serum IgG antibodies to 19 periodontal species and the prevalence of rheumatoid factor (RF) in a large nationally representative sample of adults.

Methods

The Third National Health and Nutrition Examination Survey is a cross-sectional sample of the non-institutionalized US population (n=33,994). Our study population included all dentate participants ≥60 years, who did not have RA as defined by a modified version of the American College of Rheumatology 1987 criteria, and had complete data for both serum IgG antibodies against periodontal bacteria and serum RF antibody titer (n=2461).

Results

Adjusted odds ratios (ORs) (95% CI) summarizing the relationship between the 19 periodontal serum IgGs and RF seropositivity ranged from 0.53 (0.29, 0.97) to 1.27 (0.79, 2.06), and 17 of the 19 observed ORs were < 1.0. The ORs for RF seropositivity among participants with elevated Prevotella intermedia [0.53 (0.29, 0.97)] and Capnocytophaga ochracea [0.54 (0.31, 0.95)] IgG were statistically significant.

Conclusion

We have found elevated periodontal IgGs to be mostly unassociated with RF seropositivity in the nationally representative NHANES III. Elevated antibody levels to P. intermedia and C. ochracea were associated with lower odds of RF seropositivity.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042803

DOI: 10.1002/art.39724
PubMed: 27110949
PubMed Central: 5042803

Affiliations:

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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title>
<p id="P1">Alterations in the microbiome, including the periodontal microbiome, may be a risk factor for rheumatoid arthritis (RA). Most studies that have analyzed this association are relatively small, focus primarily on a single periodontal pathogen (<italic>Porphyromonas gingivalis</italic>
), and are not population-based. We investigated the association between elevated serum IgG antibodies to 19 periodontal species and the prevalence of rheumatoid factor (RF) in a large nationally representative sample of adults.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">The Third National Health and Nutrition Examination Survey is a cross-sectional sample of the non-institutionalized US population (n=33,994). Our study population included all dentate participants ≥60 years, who did not have RA as defined by a modified version of the American College of Rheumatology 1987 criteria, and had complete data for both serum IgG antibodies against periodontal bacteria and serum RF antibody titer (n=2461).</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Adjusted odds ratios (ORs) (95% CI) summarizing the relationship between the 19 periodontal serum IgGs and RF seropositivity ranged from 0.53 (0.29, 0.97) to 1.27 (0.79, 2.06), and 17 of the 19 observed ORs were < 1.0. The ORs for RF seropositivity among participants with elevated <italic>Prevotella intermedia</italic>
 [0.53 (0.29, 0.97)] and <italic>Capnocytophaga ochracea</italic>
 [0.54 (0.31, 0.95)] IgG were statistically significant.</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P4">We have found elevated periodontal IgGs to be mostly unassociated with RF seropositivity in the nationally representative NHANES III. Elevated antibody levels to <italic>P. intermedia</italic>
 and <italic>C. ochracea</italic>
 were associated with lower odds of RF seropositivity.</p>
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Association between serum antibodies to periodontal bacteria and rheumatoid factor in NHANES III

Association between serum antibodies to periodontal bacteria and rheumatoid factor in NHANES III

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Abstract

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